H2N2V1, Main, Exploration, bibRecord, 001C94

Genetic stability of cold-adapted A/Leningrad/134/47/57 (H2N2) influenza virus: sequence analysis of live cold-adapted reassortant vaccine strains before and after replication in children.

Identifieur interne : 001C94 ( Main/Exploration ); précédent : 001C93; suivant : 001C95

Genetic stability of cold-adapted A/Leningrad/134/47/57 (H2N2) influenza virus: sequence analysis of live cold-adapted reassortant vaccine strains before and after replication in children.

Auteurs : A I Klimov [États-Unis] ; A Y Egorov ; M I Gushchina ; T E Medvedeva ; W C Gamble ; L G Rudenko ; G I Alexandrova ; N J Cox

Source :

The Journal of general virology [ 0022-1317 ] ; 1995.

RBID : pubmed:7782782

Descripteurs français

KwdFr :
- Acclimatation, Amorces ADN, Basse température, Codon, Données de séquences moléculaires, Enfant, Génome viral, Humains, Russie, Réaction de polymérisation en chaîne, Réplication virale, Sous-type H2N2 du virus de la grippe A, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie).
MESH :
- génétique : Virus de la grippe A.
- immunologie : Virus de la grippe A.
- physiologie : Virus de la grippe A.
- Acclimatation, Amorces ADN, Basse température, Codon, Données de séquences moléculaires, Enfant, Génome viral, Humains, Russie, Réaction de polymérisation en chaîne, Réplication virale, Sous-type H2N2 du virus de la grippe A, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Vaccins antigrippaux, Vaccins atténués.

English descriptors

KwdEn :
- Acclimatization, Amino Acid Sequence, Base Sequence, Child, Codon, Cold Temperature, Conserved Sequence, DNA Primers, Genome, Viral, Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines, Molecular Sequence Data, Polymerase Chain Reaction, Russia, Vaccines, Attenuated, Virus Replication.
MESH :
- chemical : Codon, DNA Primers, Influenza Vaccines, Vaccines, Attenuated.
- geographic : Russia.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- physiology : Influenza A virus.
- Acclimatization, Amino Acid Sequence, Base Sequence, Child, Cold Temperature, Conserved Sequence, Genome, Viral, Humans, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data, Polymerase Chain Reaction, Virus Replication.

Abstract

We previously reported that the A/Leningrad/134/47/57 (H2N2) cold-adapted virus (A/Len/47) used in preparing reassortant live attenuated vaccines for children acquired 14 (11 coding) mutations in genes coding for proteins other than haemagglutinin and neuraminidase during cold-adaptation. Preservation of these mutations in genomes of viruses isolated from children on the second, fifth, or eighth day after vaccination was examined by sequence analysis. The sequence data demonstrated that all nine coding mutations selected for examination were conserved in the genomes of all 11 strains investigated, indicating that the mutations accompanying cold-adaptation and attenuation of the A/Len/47 master vaccine are highly stable.

DOI: 10.1099/0022-1317-76-6-1521
PubMed: 7782782

Affiliations:

États-Unis

Le document en format XML

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<term>Amino Acid Sequence</term>
<term>Base Sequence</term>
<term>Child</term>
<term>Codon</term>
<term>Cold Temperature</term>
<term>Conserved Sequence</term>
<term>DNA Primers</term>
<term>Genome, Viral</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (physiology)</term>
<term>Influenza Vaccines</term>
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<term>Polymerase Chain Reaction</term>
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<term>Vaccines, Attenuated</term>
<term>Virus Replication</term>
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<term>Amorces ADN</term>
<term>Basse température</term>
<term>Codon</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Génome viral</term>
<term>Humains</term>
<term>Russie</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Réplication virale</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (physiologie)</term>
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<term>DNA Primers</term>
<term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
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<term>Conserved Sequence</term>
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<term>Molecular Sequence Data</term>
<term>Polymerase Chain Reaction</term>
<term>Virus Replication</term>
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<term>Amorces ADN</term>
<term>Basse température</term>
<term>Codon</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Génome viral</term>
<term>Humains</term>
<term>Russie</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Réplication virale</term>
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<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">We previously reported that the A/Leningrad/134/47/57 (H2N2) cold-adapted virus (A/Len/47) used in preparing reassortant live attenuated vaccines for children acquired 14 (11 coding) mutations in genes coding for proteins other than haemagglutinin and neuraminidase during cold-adaptation. Preservation of these mutations in genomes of viruses isolated from children on the second, fifth, or eighth day after vaccination was examined by sequence analysis. The sequence data demonstrated that all nine coding mutations selected for examination were conserved in the genomes of all 11 strains investigated, indicating that the mutations accompanying cold-adaptation and attenuation of the A/Len/47 master vaccine are highly stable.</div>
</front>
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Serveur d'exploration H2N2

Genetic stability of cold-adapted A/Leningrad/134/47/57 (H2N2) influenza virus: sequence analysis of live cold-adapted reassortant vaccine strains before and after replication in children.

Genetic stability of cold-adapted A/Leningrad/134/47/57 (H2N2) influenza virus: sequence analysis of live cold-adapted reassortant vaccine strains before and after replication in children.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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